In this study, the several risk factors associated with retinopathy were evaluated and showed that many factors are associated with retinopathy including :age, duration of diabetes, history of ischemic heart disease, nephropathy, neuropathy, insulin consumption, family history of diabetes, body mass index (BMI), serum hemoglobin level, HbA1c, FBS, BS2hpp, BUN and creatinine. This evidence concerns the gene INS and kidney disorder.