The mean age was 54.6±10.6 years, diabetic retinopathy was found in 990 (64.1%) patients, the frequency of non-proliferative diabetic retinopathy was 37.3% and proliferative was 26.8%.Age, duration of diabetes, FBS, HbA1C, BUN, Cr, Hb were significantly different between the patient’s with diabetic retinopathy and no diabetic retinopathy (p<0.05). This evidence concerns the gene GSTM1 and diabetic retinopathy.