In this study, the several risk factors associated with retinopathy were evaluated and showed that many factors are associated with retinopathy including :age, duration of diabetes, history of ischemic heart disease, nephropathy, neuropathy, insulin consumption, family history of diabetes, body mass index (BMI), serum hemoglobin level, HbA1c, FBS, BS2hpp, BUN and creatinine. The gene discussed is INS; the disease is coronary artery disorder.