The study of Pradeepa et al. showed that the duration of diabetes, the level of HbA1c, insulin treatment and males are significantly associated with the severity of retinopathy (18); Malek Madani’s study found that the factors related to retinopathy include high blood pressure, increased serum creatinine, duration of diabetes, nephropathy and diabetic foot (15). The gene discussed is INS; the disease is hypertensive disorder.