TCRγδ+LAP+ cells induced proliferation and Foxp3 expression in the transferred CD4 T cells in the SI-LP and spleen, but not in the LI-LP, suggesting that TCRγδ+LAP+ cells preferentially migrate to the SI-LP, where they control colitis by increasing the Foxp3+ Treg cell compartment and by switching the intestinal milieu from an inflammatory to a regulatory one. The gene discussed is CD4; the disease is colitis.