ANXA2 and cancer: AnxA2 is upregulated in several cancer types (Lokman et al., 2011) and in some cancer cell lines only phosphorylated AnxA2 is detected (Chiang et al., 1996), supporting a role for AnxA2 phosphorylation in cell survival and proliferation (Kumble et al., 1992; Chiang et al., 1996).