HDAC6 and colorectal cancer: Interestingly, when we analyzed lung (TCGA LUAD)-specific and colorectal cancer (TCGA COAD-READ)-specific HDAC6 regulons, generated by ARACNe analysis of the corresponding TCGA datasets, we obtained a list of 147 and 138 genes, respectively, for which thge overlap with the breast cancer regulon was highly significant (Fig. 4b).