The high level of expression of PIM1 and PIM2 in ABC-DLBCL (Additional file 1: Figure S1) and the reported synergistic effect of these two kinases with c-MYC in several cancers, prompted us to test the efficiency of the pan-PIM kinase inhibitor AZD1208 in preventing proliferation of aggressive NHL-derived cell lines. This evidence concerns the gene PIM1 and cancer.