Meanwhile, the prevalence of BRCA1 methylation in Asians (OR = 4.03, 95%CI 1.07–15.18, P = 0.04) was higher than that in Caucasians (OR = 3.16, 95%CI 1.78–5.62, P < 0.001) and in Australians (OR = 3.27, 95%CI 1.37–7.84, P = 0.008) in breast cancers compared with non-cancer controls. This evidence concerns the gene BRCA1 and cancer.