The results of our study confirmed that BRCA1 promoter methylation was significantly correlated with the increased risk of breast cancer and associated with lymph node metastasis, histological grade 3, ER(-), PR(-), triple-negative phenotype and BRCA1 protein expression, which indicated that BRCA1 promoter methylation may be utilized as an effective biomarker in the management of breast tumors. Here, PGR is linked to breast neoplasm.