SOCE in pancreatic acinar and ductal cells occurs predominantly via Orai channels and is regulated in part by TRP channels.42 Previously we found inhibition of Orai to markedly reduce CER-AP, TLCS-AP and FAEE-AP.15 Inhibition of TRPC3 was found to reduce a mild model of CER-AP,16 while the non-selective cation channel TRPV143, 44 as well as TRPA144 have been implicated in neurogenic inflammation contributing to AP. The gene discussed is TRPC3; the disease is alkaline phosphatase measurement.