Since pancreatic trypsin activity peaks very early after induction of AP in the bile acid-induced model, this parameter was not included for severity assessment.36 Caffeine significantly reduced serum amylase (figure 7A), pancreatic oedema (figure 7B), pancreatic MPO activity (figure 7C) and serum IL-6 (figure 7E), but did not affect lung MPO activity (figure 7D). This evidence concerns the gene IL6 and alkaline phosphatase measurement.