The association between lung cancer and 4 target genes (FZD8, LRP5, PIAS1 andRUNX1) has been previously reported [30–33].It has been reported that FZD8is highly expressed in A549 cell line and the dysregulation of FZD8 might play key roles in human cancer through activation of beta-catenin-TCF pathway [30]. This evidence concerns the gene LRP5 and cancer.