In the comparison of SCLC vs. normal (Fig 2C), strong negative correlations were found between the expression level of miR-375 and that of 6 putative target mRNAs (FZD8, ITGA10, ITPKB, LRP5, PIAS1 and RUNX1), while strong positive correlations were observed between the expression of miR-375 and that of 4 putative target mRNAs (ACSL3, NLK, PDPK1 andSP1). The gene discussed is NLK; the disease is small cell lung carcinoma.