While there was no functional enrichment of fast evolving genes among genes differentially expressed between preeclampsia or birth with labor and normal or birth without labor, respectively, a number of genetic pathways differs between fast evolving PE and LED genes (S1 Table), possibly highlighting contrasting axes along which these two clinical subtypes segregate (there were too few PPROM and sPTB fast evolving genes for meaningful comparisons). This evidence concerns the gene SPTB and preeclampsia.