A number of fast evolving, placental genes show tumorigenic or tumor suppression activity (ADAM12, ADAMTS18, CAPN6, EGFL6, HTRA4, LIN28B) and others are involved in disorders associated with epithelial and connective tissues (FBN2) or have immune functions (IL1RL1, PRG2, SIGLEC6). This evidence concerns the gene ADAMTS18 and neoplasm.