ADAM12 and neoplasm: A number of fast evolving, placental genes show tumorigenic or tumor suppression activity (ADAM12, ADAMTS18, CAPN6, EGFL6, HTRA4, LIN28B) and others are involved in disorders associated with epithelial and connective tissues (FBN2) or have immune functions (IL1RL1, PRG2, SIGLEC6).