A number of fast evolving, placental genes show tumorigenic or tumor suppression activity (ADAM12, ADAMTS18, CAPN6, EGFL6, HTRA4, LIN28B) and others are involved in disorders associated with epithelial and connective tissues (FBN2) or have immune functions (IL1RL1, PRG2, SIGLEC6). Here, FBN2 is linked to neoplasm.