IFNA1 and cancer: Along with mutations that promote accelerated proliferation and invasion, many cancerous cells lose their ability to produce and respond to interferon (IFN) by apoptotic pathway induction.24 Such abnormalities make these cells highly susceptible to viral infection.25 So, due to the abundance of cancer-specific receptors, cancer-specific genetic defects, and proteases, oncolytic paramyxoviruses are more likely going to spread among malignant than among normal cells.