NCR1 and neoplasm: Hemagglutinin neuraminidase (HN) protein of paramyxoviruses directly interacts with two receptors types: NKp44 and NKp46, and this interaction triggers the NK activation and NK-mediated cell lysis.93–96 In particular mumps viral HN protein mediates NKp46 activation of NK cells, and this activation results in tumor rejection via NK-DC crosstalk.97 Studies with the UV-inactivated SeV virus also highlight the important role of NK cells in virus-mediated oncolysis.