The attenuated measles virus (Edmonston strain) (MVES) uses the CD46 receptor, which is a regulator of complement activation that is universally expressed in all nucleated human cells but is often overexpressed in tumor cells.10 MVES can kill cells that overexpress this receptor without significant cytopathic effect against nontransformed cells expressing low receptor levels.11 Nectin 4 has recently been identified as the additional receptor for MV.12 It is a member of adhesion receptors of the immunoglobulin superfamily localized to the adherents’ junctions of epithelial cells. This evidence concerns the gene NECTIN4 and neoplasm.