Interestingly, this indirect mode of Akt protein activation appears to be important for the viability of thyroid carcinoma and multiple myeloma cells [35]. DEPTOR overexpression and reduced mTORC1 complex activity have been detected in approximately 28% of patients with multiple myeloma, and these patients had lower survival rates [35]. The gene discussed is AKT1; the disease is thyroid gland carcinoma.