Not surprisingly, along the last years, there has been a great increase in the number of publications focusing on the metabolic alterations and menopause-related symptoms in OVX models, such as early aging of nervous and immune system [34], weight gain [35], behavioral changes [23], cardiovascular dysfunction [36], insulin resistance [37, 38], and alterations in cytokines levels (e.g., TNF-α, IL-1, IL-6, and IL-10) [39]. This evidence concerns the gene TNF and Insulin resistance.