BIRC5 and diffuse large B-cell lymphoma: Liu et al. [40] investigated survivin expression in 463 R-CHOP-treated DLBCL patients: 269 (58 %) had survivin overexpression (cutoff of >25 % positive cells), associated with high IPI score, disease in ≥2 extranodal sites, and a high Ki-67 index; in ABC type, survival of survivin-positive patients was lower; cases with wild-type p53 and surviving overexpression had lower survival rates; in STAT3-positive cases, survivin overexpression was associated with better survival.