The lack of effect on cell death is consistent with the reemergence of spontaneous seizures after cessation of rapamycin treatment in previous reports and suggests that important components of the underlying injury that triggers the eventual development of epilepsy are not abrogated by mTOR inhibition, even though several other cellular correlates of epileptogenesis are suppressed during high-dose rapamycin treatment. Here, MTOR is linked to epilepsy.