This finding was further corroborated by the qRT-PCR analysis of the typical M1 markers IL-1β, IL-6, and TNF-α as well as M2 markers IL-10, MMP9, and TGF-β (Courties et al., 2014), which were comparable between SHR and WKY after stroke (Figure 6). Here, MMP9 is linked to stroke disorder.