Mechanistically, earlier studies indicate that monensin was shown to decrease levels of CDK6, cyclin D1 and cyclin A and to induce apoptosis-associated changes in Bax, caspase-3, caspase-8 and mitochondria transmembrane potential in several human cancer cell lines13, 14, 15, 16, 17. The gene discussed is CCNA2; the disease is cancer.