To identify novel functions driven by E2f factors during TKO HCC development, we performed a computational analysis of the recently published TKO HCC transcriptome11 and identified a set of genes (Glut4, Pygb, Gsk3b, Pkm2, Pfkl and Mct1) that displays increased expression in TKO HCC. The gene discussed is PYGB; the disease is hepatocellular carcinoma.