However, our MS approach as well as ChIP assay for Tip60 protein in TKO HCC cells failed to identify a role for these larger complexes in TKO HCC, suggesting that E2f1 recruits isolated Pontin/Reptin complexes in TKO HCC (Supplementary Fig. 3c and Supplementary Data 5). The gene discussed is RUVBL2; the disease is hepatocellular carcinoma.