Importantly, Reptin knock-down repressed the expression of a panel of E2f target genes (Fig. 5c and Supplementary Fig. 4a) to ∼2-fold, which is similar to the repression observed upon expression of Rb-7LP in TKO HCC cells (Fig. 1d and Supplementary Fig. 4b) and correlate with the 2-fold amplification observed from early to late lesions (Fig. 2c–e). The gene discussed is RUVBL2; the disease is hepatocellular carcinoma.