These assays showed that E2f1, but not E2f2 or E2f3, interacts with Pontin and Reptin in TKO HCC (Fig. 4a–d, see Supplementary Fig. 7a,b for the uncropped autoradiogram of Fig. 4a,c, respectively). The gene discussed is RUVBL1; the disease is hepatocellular carcinoma.