Results shown in Fig. 5 indicate that the recruitment of Pontin/Reptin by E2f1 opens chromatin at E2f target genes (as evidenced by the decreased presence of H2a.z and the reduced DNAseI sensitivity upon Reptin silencing in TKO HCC cells), which impacts the capacity of E2f factors to bind to their target genes. The gene discussed is E2F1; the disease is hepatocellular carcinoma.