When the 19 EGFR-mutant NSCLC patients of the validation cohort were grouped as EGFR TKI responders and non-responders according to BIM mRNA expression, 85.72% of patients with high BIM responded to EGFR TKIs vs 50.0% patients with low/intermediate BIM (P = 0.3240). This evidence concerns the gene EGFR and non-small cell lung carcinoma.