In glioblastoma and melanoma cells, diacylglycerol kinase α (DGKα), a lipid kinase converting diacylglycerol to phosphatidic acid, regulates both mTOR activity and MTOR mRNA levels via modulation of cyclic adenosine monophosphate (cAMP) (Fig. 1)12, 13. This evidence concerns the gene MTOR and melanoma.