The RISC-capture assay also demonstrated that several kinds of mRNA showed less inclusion in RISC from BCR-activated DLBCL biopsy samples (n = 3; DLBCL#1 is GC-DLBCL; DLBCL#2 and DLBCL#3 are non-GC-DLBCL) than in normal B cells (Fig. 4c,d). The gene discussed is BCR; the disease is diffuse large B-cell lymphoma.