Also, we found a statistically significant association between its activity and the tumor shape irregularity measured by two radiomic phenotypes, irregularity and sphericity. We also see that the pathway has statistically significant positive associations with maximumenhancement and enhancement at first post-contrast time point, which implies that tumors with a higher JAK-STAT pathway activity have more leaky microvessels to support its growth. The gene discussed is SOAT1; the disease is neoplasm.