SGO1 and B-cell chronic lymphocytic leukemia: In summary, by characterizing a lower-risk CLL cohort with WGS, we were able to show for the first time the operation of a distinct c-AID signature in CLL using unsupervised genome-wide analysis, and to demonstrate that this signature is in fact more abundant in cases with lower-risk mutated IGHV. These cases have fewer driver mutations and their key causative events beyond deletion 13q are still unclear.