Resveratrol suppressed expression of myocardial disease markers, atrial natriuretic factor (ANF), brain natriuretic peptide (BNP) and beta myosin heavy chain (β-MHC) (Fig. 2E) in early iron-overload which correlated with correction of iron-overload induced diastolic dysfunction (Fig. 2C,D; Supplemental Tables 2–3) without affecting myocardial iron levels (Fig. 2A,B). This evidence concerns the gene NPPA and Tangier disease.