BRF2 and squamous cell lung carcinoma: In this context, ectopic overexpression of Brf2 in lung fibroblasts (Figures 7A–7C) and mammary epithelial cells (Figure S5) reveals Brf2 oncogenic potential under oxidative stress conditions, supporting its role as an oncogenic driver in lung squamous cell carcinoma (Lockwood et al., 2010) and breast cancer (Sanchez-Garcia et al., 2014).