TXNRD1 and cancer: Major targets upregulated by Nrf2 upon oxidative stress include TrxR1 and Gpx2, two essential selenoproteins involved in the maintenance of redox homeostasis and anti-oxidant defense, which are found overexpressed in several forms of cancers (Biaglow and Miller, 2005, Brigelius-Flohé et al., 2012, Emmink et al., 2014, Naiki et al., 2014).