BRF2 and cancer: Thus, we hypothesized that overexpression of Brf2, which is also observed in many forms of cancer (Cabarcas and Schramm, 2011), is required to overcome the Brf2-dependent reduction of SeCys tRNAs observed during prolonged oxidative stress, in order to maintain sufficient expression levels of selenoproteins required for ROS detoxification and redox homeostasis.