As shown by videomicroscopic analyses, the death of tetraploid tumor cells succumbing upon MSP1 inhibition was always preceded by chromatin condensation (pyknosis) and nuclear fragmentation (karyorrhexis), two morphological hallmarks of apoptosis [66] (Figures 5A and 6A, and Supplementary Movie S6). The gene discussed is ATAD1; the disease is neoplasm.