In order to assess the functional impact of NIK-lesioned γδ T cells, we treated Map3k14-/- animals with Imiquimod, a well established system for the induction of psoriasis-like skin inflammation in mice (van der Fits et al., 2009; Cai et al., 2011; Pantelyushin et al., 2012). The gene discussed is MAP3K14; the disease is psoriasis.