However, we also show that the detailed immunopathology of demyelinating HAE is different in many respects from that seen in classical EAE models in primates and rodents, that CD8+ T-cells, CD20+ B-cells and IgM producing plasma cells may play a decisive role in the induction of the disease and that this may be similar in MS patients. This evidence concerns the gene CD40LG and hereditary angioedema.