In addition, EDB-containing fibronectin in the CSF was 5.9-fold higher compared to EDB-containing fibronectin in peripheral blood in patients with meningitis while the ratio was much lower in healthy subjects (CT: 0.2+/−0.02 vs. meningitis: 5.9+/−0.5 fold, n = 14 + 22, p < 0.0001). Here, FN1 is linked to infectious meningitis.