Finally, since NEP is involved in the degradation of the Aβ peptides, which are implicated in the development of Alzheimer's disease, concerns have been raised that NEP inhibition might produce an accumulation of Aβ peptides in plaque-like deposits in the brain [187], although studies up to 5 years of follow-up have not supported this concern. The gene discussed is MME; the disease is early-onset autosomal dominant Alzheimer disease.