Seventy-four percent of Fancj−/− mutants developed tumors, with a greater incidence in females (∼74% vs. ∼48% only in males) (Fig. 3C; Supplemental Fig. S2A), and 60% of the Fancj−/− mutant mice presented with more than one primary tumor (Fig. 3D). Here, BRIP1 is linked to neoplasm.