EZH2 and breast cancer: Even more surprising, the levels of the enzyme and the mark were found to be anti-correlated between the different breast cancer subtypes (Holm et al. 2012), and, while high expression of EZH2 correlates with poor prognosis, high levels of H3K27me3 correlate with good prognosis (Holm et al. 2012; Bae et al. 2015).