Pla2g3 induction was not observed in an acute oxidative stress accompany with the gliosis by ischemia (Fig 3E and 3F) or traumatic brain injury (Fig 3G and 3H) to the cerebral cortex, suggesting that the chronic oxidative stress is a key condition to induce Pla2g3 expression in astrocytes in vivo. Here, PLA2G3 is linked to ischemia.