CASP3 and neoplasm: Although vemurafenib treatment did not significantly affect protein levels of cleaved caspase-3, marker of apoptosis (Figure 2G), we found a significant (p=0.007) increase of about 2.5-fold human lysosomal endogenous beta-galactosidase (β-gal, senescence marker) expression in the orthotopic tumor cells in the vemurafenib-treated mice (Suppl.