MCL1 and neoplasm: Our orthotopic mouse model of tumor harboring the heterozygous BRAFV600E mutation along with MCL1 and P16 copy number alterations showed focal PTC-like nuclear features (i.e. clearing), suggesting that this mouse model may be a helpful translational tool for in vivo pre-clinical testing of anti-BRAFV600E therapy, although these tumor cells (i.e. KTC1 cells) showed in vivo mixed spindled and epithelioid features which are not characteristic of PTC.