By comparing the TF binding occurrences between 209 and 51 differential distal peaks that were up-regulated in HD and control respectively, we found that six transcription factors (ZBTB7A, E2F6, CCNT2, HMGN3, EZH2, and SUZ12) had enriched binding sites in HD-specific distal peaks and two TFs (GATA3 and KAP1) had enriched binding sites in control-specific distal peaks (Fig 5E). Here, E2F6 is linked to Huntington disease.