This finding is partly consistent with a previous report that sensitivity to BTZ was associated with the expression of several ATF genes, including ATF3, ATF4 and ATF5, in BTZ-sensitive or -resistant non-Hodgkin's B-cell lymphoma-derived cell lines.22 Higher basal expression of ATF family members may reflect cell exposure to strong ER stress. Here, ATF4 is linked to B-cell non-Hodgkin lymphoma.