Koutros and colleagues evaluated gene-environment interactions among nearly 120 polymorphisms across multiple metabolizing genes (CYP1A1, CYP1A2, CYP1B1, GSTA1, GSTM1, GSTM3, GSTP1, NAT1, NAT2, SULT1A1, SULT1A2, and UGT1A locus) and meat-derived HCAs in relation to PCa susceptibility within a subset of participants selected from the PLCO Trial [15]. Here, NAT2 is linked to posterior cortical atrophy.