Earlier studies surveyed P63 protein in odontogenic cysts and reported that staining was not observed in superficial layers of the cysts other than odontogenic keratocyst (currently known as keratocystic odontogenic tumour, KCOT) and that non-aggressive cysts showed mild expression of P63.[10-11] Immunoreactivity for this protein in luminal lining of unicystic ameloblastoma was similar to that in dentigerous cyst; however, the intensity of staining was higher and suprabasal layers showed greater percentage of stained cells. This evidence concerns the gene TP63 and odontogenic cyst.