In the case of PD, the main genes which are epigenetically regulated through methylation are SNCA, PARK6, CYP2E1, PINK1, BDNF, FGF, MAPT, MTHFR, OLFR 151, PARK16, PARK2, PARK7, TPPP, PDE4D, and METRNL. The gene discussed is SNCA; the disease is Parkinson disease.