EDN1 and hypertensive disorder: AGTR1, AGT (functional category: renin-angiotensin system), EDN1, NOS3 (functional category: endothelial integrity), and SOD2 (functional category: oxidation-reduction state), which participate in systemic arterial blood pressure regulation, are also EAT markers involved in the pathogenesis of hypertension and CVDs [20, 40, 41, 62, 76].