SEC23A and craniolenticulosutural dysplasia: Moreover, mutations in essential components of COPII-coated vesicles, such as SEC23A, sec23a and sec24d, which transport secretory proteins from the ER to Golgi, result in cranio-lenticulo-sutural dysplasia (CLSD) [36] and the Zebrafish mutants crusher[37] and bulldog[38], respectively.