In the process of establishing specific clinical phenotypes induced by various SNCA genotypes in PD, we describe here the effects induced by a novel mutation of SNCA which consists of a 351 Kb triplication containing the SNCA gene along with 6 exons of MMRN1 gene in 4q22.1 and a duplication of 1,29 Mb of the genomic region flanking the SNCA + MMRN1 triplication. Here, MMRN1 is linked to Parkinson disease.