Whether decreased testosterone level is a result of degradation of uremic metabolites accumulated mainly in testes and affecting the Leydig cells as a result of progressive kidney disease or an inhibition of cAMP production associated with inhibition of 125I-human chorionic gonadotropin binding of the luteinizing hormone receptor in Leydig cells [23] is still unknown. The gene discussed is LHCGR; the disease is kidney disorder.