Fehrenbacher et al examined the outcomes of 234 patients with HER-2+ T1ab tumours diagnosed between 2000 and 2006 and similarly the prognosis for the patients not treated with chemotherapy or trastuzumab (n = 171) was, in general, excellent, with rates of recurrence (distant and local recurrence free interval) in all subgroups of less than 10% at 5 years [22]. The gene discussed is ERBB2; the disease is neoplasm.