We have discussed the possible role of FSH-FSHR3-stem cells interaction in the OSE resulting in ovarian cancers, POF, and menopause and how the reproductive biologists have been misled by screening for mutations in FSHR1 with a focus on exon 10 whereas FSHR3 may have a more significant role (has exon 11 and lacks exons 9 & 10) thus explaining the accumulated negative data on lack of mutations in FSHR in women with POF and cancer [58]. Here, FSHR is linked to cancer.