In a comparison of the type 1 reaction with its respective clinical forms [R1 vs. (TT + BT + BB + BL)], 69 canonical pathways were identified, which play roles in Leukocyte Extravasation Signaling, MSP-RON Signaling Pathway, Glioma Invasiveness Signaling and IL-17 Signaling. The gene discussed is IL17A; the disease is glioma.