In the L-lep the up regulated genes were associated with anti-inflammatory/Th2 (TGFß1, IL-5, and latent TGFß protein-2), inhibitory receptors (SIRP-1α, LIR-7, LIR-4, LIR3 e LIR8) and B cell response (CD80, Ig heavy chain gamma 3, CD83, Ig kappa chain, anti-colorretal carcinoma heavy chain, MD-1, CD22, BLNK, rearranged Ig heavy chain, Ig lambda locus, Ig kappa light chain variable region, CD19, Ig heavy chain constant M, TNFRSF17, IgM binding protein 2 and Ig lambda-like polypeptide 1). The gene discussed is LILRB5; the disease is carcinoma.