Furthermore, of the 42 most TC-YIK enriched TFs (enrichment score > 1.25, ~18-fold enrichment over median expression levels), 33 were previously implicated in pancreatic biology, including direct regulators of insulin (Sander and German, 1997), key factors for islet cell development (Wang et al., 2005; Guo et al., 2011), genes associated with diabetes (Foti et al., 2005) and with pancreatic endocrine tumors (Johansson et al., 2008; Table 2, Supplementary Table 3). This evidence concerns the gene INS and pancreatic neuroendocrine tumor.