Activation of Type I IFN response comprising MX-1 centered signature, consisting of IFN-α/β and CXCL10; surface exposure of mannose-6-phopshate receptor, which enables better interface with CTLs and facilitates GZMB-mediated cell death; radiotherapy is known to increase expression levels of various antigens in number of cancer models as well as induce “abscopal effect” in both preclinical and clinical models; overall CALR levels were predictive of prolonged OS in radiotherapy-treated lung cancer patients. The gene discussed is MX1; the disease is lung cancer.