In patients of eosophageal squamous cell carcinoma (ESCC) receiving chemo-radiotherapy significant increase in serum HMGB1-levels and increased intra-tumoral staining of HMGB1 correlated with better patient survival (232); high tumoral CALR levels in radiotherapy-treated lung cancer patients associated with prolonged OS as well as increased expression levels of various phagocytosis-associated genes (42). Here, HMGB1 is linked to lung cancer.