Colocalization of CD14+ cells with clusters of CD4+ effector T cells at sites of inflammation has been reported in inflamed rheumatoid synovium, as well as in inflamed tonsil, and psoriatic or atopic dermatitis skin (41, 42), suggesting that CD4+ T cells and monocytes/macrophages can interact in vivo at sites of inflammation. Here, CD4 is linked to atopic eczema.