SLC15A1 and colitis: Nevertheless, a recent study argues against the indication of a role for PepT1 in the development of intestinal inflammation, showing that in animal models resembling Crohn-like ileitis (TNFdeltaARE) and colitis (IL-10−/−, IL-10XTLR2−/−, and Rag2−/−) and in human intestinal tissues from IBD patients, severity of inflammation correlated with lowered PepT1 expression levels (146).