Similar causality may be involved in the cognitive impact of RH: glucocorticoid receptors (GRs) are expressed at high levels in the hippocampus (62, 63), and GCs have been extensively shown to mediate hippocampal damage from metabolic stressors (such as hypoglycemia): specifically, GCs exacerbate damage from inadequate glucose supply (64–66) and are linked to excitotoxic cell death following severe hypoglycemia. This evidence concerns the gene BCL2A1 and Hypoglycemia.