When we tested this, we found that there were a panel of 10 proteins (transthyretin, clusterin, cystatin C, A1AcidG, ICAM1, complement component C4, PEDF, A1AT, RANTES, and ApoC3) along with APOE genotype, which were able to predict MCI conversion to AD with 87% accuracy, 85% sensitivity, and 88% specificity, as described earlier (124). This evidence concerns the gene CLU and Alzheimer disease.