CLU and Mental deterioration: For example, the apolipoprotein family is widely implicated in neurodegeneration (157, 158) and in a targeted study, Song et al. showed a negative correlation of plasma clusterin and ApoE with gray matter volume and an association of ApoA1, ApoA2, ApoH, and the ApoB/ApoA1 ratio with risk of cognitive decline in cognitively normal individuals (130).