It is also worth noting that evidence for clusterin being implicated in AD pathology has also been provided on the genetic level, with an association of the variant rs11136000 in the clusterin gene with AD risk (153, 154), increased rates of cognitive decline at the pre-symptomatic stages of the disease (155) and brain volume and structure (volumetric expansion and lateral ventricle surface morphology) in AD, MCI, and elderly control subjects (156). Here, CLU is linked to Alzheimer disease.